Effect of antiepileptic drugs on the level of plasma homocysteine and asymmetric dimethyl arginine in epileptic patients

VernacularTitle:奥卡西平和丙戊酸钠对癫痫患者血浆同型半胱氨酸和不对称二甲基精氨酸水平的影响
Author: Jie XIA ; Zheng ZHENG ; Qimei ZHANG
Publication Type:Journal Article
Keywords: epilepsy; oxcarbazepine; valproate; homocysteine; asymmetric dimethyl arginine
From: Chongqing Medicine 2015;(6):783-784
CountryChina
Language:Chinese
Abstract: Objective To investigate plasma homocysteine(Hcy)and asymmetric dimethyl arginine(ADMA)concentration in patients with epilepsy receiving oxcarbazepine(OXC)or sodium valproate(VPA)monotherapy.Methods Plasma were collected from 32 cases of OXC and 36 cases of VPA monotherapy.The levels of hcy and ADMA were detected and compared with healthy controls.Then the correlation of the levels and antiepileptic drug treatment duration was analyzed.Results The levels of hcy and ADMA in treatment groups were higher than in control gruops(P <0.05),and no difference between two treatment groups(P >0.05).Antiepileptic drug treatment duration and plasma Hcy,ADMA levels were positively correlated (r =0.274,P <0.05;r =0.256,P <0.05).Conclusion OXC and VPA elevated hcy and ADMA plasma levels in patients with epilepsy.Routine monitoring of plasma hcy and ADMA and supplementation of B vitamins and folate acid might have help to reduce thrombotic events occurring for patients receiving long-term OXC and VPA therapy.