The effect of periodontal flap therapy on the levels of serum TNF-α,IL-6 and CRP in elderly coronary heart disease
10.3969/j.issn.1671-8348.2015.06.024
- VernacularTitle:翻瓣术对老年重度牙周炎冠心病患者血清 TNF-α、IL-6和 CRP 水平的影响
- Author:
Lizhen ZHOU
;
Li HUANG
- Publication Type:Journal Article
- Keywords:
severe periodontitis;
coronary heart disease;
tumor necrosis factor-alpha;
interleukin-6;
c-reactive protein;
periodontal flap therapy
- From:
Chongqing Medicine
2015;(6):785-787
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of different periodontal therapies on serum levels of tumor necrosis factor-alpha (TNF-α),interleukin-6(IL-6)and C-reactive protein (CRP)in elderly patients with coronary.Methods Totally 90 elderly patients with severe periodontitis were divided into three groups,the control group performed the treatment of coronary heart disease;the periodontal treatment group performed the treatment of coronary heart disease and periodontal treatment;the combine group per-formed periodontal therapy and flap surgery on the basis of the treatment of coronary heart disease.The obvervational index were compared among three groups.Results All patients′clinical indexes of periodontitis of combination group and basic group has im-proved after treatment,the levels of PD,SBI,CAL,PLI,the percentage of bleeding on probing and probing depth were significantly decreased (P <0.05),and had significant adhesion(P <0.05);the contrast between combination group and basic group,the levels of PD,SBI,CAL,the percentage of bleeding on probing and probing depth had notable difference(P <0.05).All patients′clinical indexes of periodontitis of combination group and basic group had improved after treatment,serum levels of TNF-α,IL-6 and CRP were significantly decreased (P <0.05);the contrast between combination group and basic group,serum levels of TNF-α,IL-6 and CRP have notable difference (P <0.05).Conclusion The periodontal basic therapy and periodontal flap therapy can reduce the ser-um levels of TNF-α,IL-6 and CRP of elderly coronary heart disease (CHD),but compared to the routine medicine maintenance therapy,the effect of periodontal flap therapy is better.
