Analysis of fetal chromosomal karyotypes in 1 160 pregnant women during the first trimester of gestation

VernacularTitle:1160例孕早期绒毛染色体细胞遗传学分析
Author: Luping OUYANG ; Shaoke CHEN ; Dongmei FEI ; Tiansheng LIU ; Hongqian HUANG ; Chenguang ZHENG
Publication Type:Journal Article
Keywords: prenatal diagnosi; karyotype analysis; first trimester; chorionic villus cells
From: Chongqing Medicine 2015;(6):813-815
CountryChina
Language:Chinese
Abstract: Objective To evaluate the value of chorionic villus cells karyotype analysis in prenatal diagnosis during the first tri-mester of pregnancy.Methods Pregnant women with prenatal diagnosis indications were punctured by guiding abdominal B-mode ultrasound to get villi tissue which was then to develop cell culture,chromosome preparation and karyotype analysis.Results A to-tal of 1 140 cases were successfully cultured,and the successful cultivating rate was 98.2% (1 140/1 160).Among them,chromo-somes of 62 cases were detected to be non-polymorphic structural abnormalities,including 32 abnormal chromosome number,5 chro-mosome balanced translocation,3 chromosome deletion,and 22 chimeras.What′s more,20 cases were detected to be chromosomal inversion,19 cases of chromosome 9 were inversion,and one with chromosome Y was inversion.Conclusion Karyotype analysis of villus cell could help to detect fetal chromosomal abnormalities during early pregnancy and get early intervention.It was significant to reduce the child′s birth with chromosome abnormalities.