Correlation between the severity of knee osteoarthritis and levels of chemerin in serum and synovia
10.3969/j.issn.2095-4344.2015.02.003
- VernacularTitle:膝骨关节炎严重程度与关节液和血清中chemerin含量的关系
- Author:
Guoqing DUAN
;
Chunfeng REN
- Publication Type:Journal Article
- Keywords:
Knee Osteoarthritis;
Cytokines;
Enzyme-Linked Immunosorbent Assay
- From:
Chinese Journal of Tissue Engineering Research
2015;(2):177-181
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Studies have found that after stimulation, chemerin can further amplify the inflammatory signal, resulting in the release of inflammatory factors and matrix metaloproteinases. It indicates that chemerin may serve as an important regulator of cartilage metabolism, and plays an important role in the pathogenesis of osteoarthritis. OBJECTIVE: To explore the correlation between level of chemerin in synovia and serum and severity of knee osteoarthritis. METHODS: Eighty patients with knee osteoarthritis were enroled in the study. Knee osteoarthritis grading was evaluated according to the Kelgren-Lawrence classification. Chemerin levels in synovia and serum were examined with enzyme-linked immunosorbent assay. RESULTS AND CONCLUSION:The level of chemerin in synovia and serum in patients with knee osteoarthritis were positively correlated with the Kelgren-Lawrence classification (r=0.981,P< 0.001;r=0.901,P < 0.001). And there was a positive correlation between the level of chemerin in synovia and in serum (r=0.596,P < 0.01). Experimental findings suggest that the levels of chemerin in synovial fluid and serum that are positively correlated with the Kelgren-Lawrence classification can be used as a reference biomarker of severity of knee osteoarthritis.
