Association between the rs1007888 polymorphism of macrophage migration inhibitory factor gene and coronary heart disease in the Kazakhs of China
10.3969/j.issn.2095-4344.2015.02.013
- VernacularTitle:巨噬细胞移动抑制因子基因rs1007888位点单核苷酸多态性与哈萨克族冠状动脉粥样硬化性心脏病发病的相关性
- Author:
Rui XU
;
Yining YANG
;
Yitong MA
;
Xiaomei LI
;
Qian ZHAO
;
Bangdang CHEN
;
Fen LIU
- Publication Type:Journal Article
- Keywords:
Polymorphism,Single Nucleotide;
Genotype;
Aleles;
Gene Frequency
- From:
Chinese Journal of Tissue Engineering Research
2015;(2):231-235
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Macrophage migration inhibitory factor (MIF) is a multi-potent cytokine that makes considerable contribution to the regulation of inflammatory response and immune response in the body. MIF rs1007888 is associated with various inflammatory diseases, but the correlation between rs1007888 and coronary heart disease in the Kazakhs of China has been rarely explored. OBJECTIVE:To investigate the relationship between rs1007888 gene polymorphisms in MIF gene and coronary heart disease in the Kazakhs from Xinjiang Uygur Autonomous Region, China. METHODS:A total of 230 Kazakh patients with coronary heart disease evidenced by coronary arteriography between December 2012 and July 2014 were recruited, and another 478 Kazak controls were free from coronary artery disease with normal angiograms. Real-time fluorescence quantitative PCR assay was used to detect the rs1007888 polymorphisms of MIF gene. Alele and genotype distributions of the rs1007888 polymorphism were compared between patients and controls. RESULTS AND CONCLUSION:Distribution of genotypes in the two groups appeared to be in Hardy-Weinberg equilibrium (P> 0.05). The alele frequencies and genotypes of MIF-rs1007888 showed no significant difference between the two groups (P > 0.05). Therefore, the genetic variation of rs1007888 in MIF gene is not associated with coronary heart disease in the Kazakhs of China.
