Clinical significance of increased plasma IGF-1 in type 2 diabetic patients with malignant tumor
10.3969/j.issn.1671-8348.2015.05.017
- VernacularTitle:2型糖尿病肿瘤患者IGF-1变化的临床意义
- Author:
Yu CHEN
;
Yingyu NAN
;
Guo YE
- Publication Type:Journal Article
- Keywords:
diabetes mellitus,type 2;
insulin-like growth factor Ⅰ;
malignant tumor
- From:
Chongqing Medicine
2015;(5):628-630
- CountryChina
- Language:Chinese
-
Abstract:
Objective To test plasma insulin‐like growth factor 1(IGF‐1) level in type 2 diabetic patients with malignant tumor , and make comparison with diabetic patients and normal patients .To discuss the significance of detection of plasma IGF‐1 level in type 2 diabetes in screening early malignant tumor .Methods Plasma IGF‐1 level were determined in type 2 diabetes among malig‐nant tumor group ,type 2 diabetes ,and normal control group ,and statistical comparison was made between the three groups .Results the plasma levels of IGF‐1 of type 2 diabetes mellitus ,type 2 diabetes mellitus with malignant tumor were significantly lower than normal group(P<0 .05) .And the plasma level of IGF‐1 in type 2 diabetes mellitus with malignant tumor group was obviously high‐er than that of type 2 diabetic group(P<0 .05) .Plasma IGF‐1 ,FBG ,HbA1c and 2 HBG level are risk factors for tumor .The level of FIns is a protective factor for tumor .Conclusion Type 2 diabetes is closely related to the malignant tumor ,and the plasma levels of IGF‐1 is a risk factor for tumor .
