Effect of mlodipine/hydrochlorothiazide in patients with essential hypertension：A systematic review
10.3969/j.issn.1671-8348.2015.05.034
- VernacularTitle:氨氯地平与缬沙坦分别联合氢氯噻嗪对控制原发性高血压血压的系统评价
- Author:
Tianyong LUO
;
Yimei LI
;
Bo XIE
;
Linna HAN
;
Lian JIANG
;
Qianpei HU
;
Qiong LI
- Publication Type:Journal Article
- Keywords:
amlodipine;
valsartan;
hydrochlorothiazide;
essential hypertension;
systematic review
- From:
Chongqing Medicine
2015;(5):673-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy and safety of amlodipine (A)/hydrochlorothiazide(H) versus val‐sartan(V)/hydrochlorothiazide(H) in treatment of essential hypertension .Methods Literature was retrieved online in Cochrane Li‐brary ,PubMed ,OVID ,MEDLINE ,EMBASE ,CBM ,CNKI ,VIP and Wan fang database up to November 2013 .Relevant magazines were retrieved manually .Quality of the included studies was assessed and Meta‐analysis was performed with RevMan 5 .2 software . Results Seven randomized controlled trials(RCTs) were finally included .Meta‐analyses showed that :in terms of lowering ABP ,V/H group was more effective than A/H group ,the difference was statistically significant (P<0 .05);there was no significant differ‐ence in the decreased value of clinic BP and the control rate of blood pressure between A /H group and V/H group(P>0 .05) .Ad‐verse events occurred less frequently with V/H group compared with A/H group ,the difference was statistically significant (P<0 .05) .Conclusion A/H treatment of essential hypertension is inferior to V/H ,and has more adverse events .
