Dynamic changes of the serum pro-and anti-inflammatory cytokines and its significance in assessing clinical condition for sepsis patients
10.3969/j.issn.1671-8348.2015.04.012
- VernacularTitle:脓毒血症患者抗炎和促炎指标动态变化在临床病情评估中的意义
- Author:
Minghua SU
;
Xuanling FENG
;
Lei DENG
;
Yi LI
;
Junying LI
;
Youdai CHEN
- Publication Type:Journal Article
- Keywords:
sepsis;
tumor necrosis factor-alpha;
interleukin-1;
interleukin-4;
interleukin-10
- From:
Chongqing Medicine
2015;(4):467-469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic change of pro‐and anti‐inflammatory eytokines of sepsis patients and its signif‐icance in clinical condition .Methods Forty‐three sepsis patients from 2010 to 2011 were divided into the survival group and the death group .Morning serum samples were collected on the first ,third ,firth and seventh day morning ;ELISA method was used to quantify the serum level of TNF‐α,IL‐1 ,IL‐4 and IL‐10 .The severity of patient′s condition was assessed according to the APACHEⅡsystem .Results In the early stage ,TNF‐α and IL‐1 in of both group increased and reached the peak on the third day ;then there was a gradual decline .Test in the same time point showed that the indexes of death group were all higher than that of survival group (P<0 .05) .IL‐4 of the two groups reached its peak on the fifth day and then declined ,and in the same time point ,indexes of death group were much more higher than that of survival group (P<0 .05) .IL‐10 of the survival group reached its peak on the fifth day and then declined;in the death group ,IL‐10 level kept increasing and maintained high ,there was no significant difference among the serum levels of the third ,fifth and seventh day(P>0 .05) .The APACHE Ⅱ of the survival group declined significantly while in death group it kept increasing and stay high .Conclusion Pro‐inflammatory eytokines(TNF‐α,IL‐1) ascended earlier than anti‐in‐flammatory eytokines(IL‐4 ,IL‐10) ,and the serum level of IL‐10 keep high level prompt the poor prognosis .
