Clinical study on the anti-helicobacter pylori treatment on immune thrombocytopenia in children
10.3969/j.issn.1671-8348.2015.04.017
- VernacularTitle:联合抗幽门螺杆菌治疗儿童免疫性血小板减少症的临床研究
- Author:
Ying TANG
;
Changgang SUN
;
Yong LIU
;
Haiying WANG
;
Zhanju WANG
- Publication Type:Journal Article
- Keywords:
thrombocytopenia;
helicobacter pylori;
child;
lymphocyte subsets;
platelet associated immunoglobulin
- From:
Chongqing Medicine
2015;(4):482-484
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinic character of immune thrombocytopenia (ITP) children infected with helicobacter py‐lori (Hp) and the effects of anti‐helicobacter pylori treatment on those children .Methods One hundred and forty‐two ITP children and 92 healthy children were conducted the 13C‐Urea breath test to determine the infections of Hp .The ITP children infected with Hp were divided into two groups :single drug group (48 cases ,treated only with corticosteroid ) and combined drugs group (49 ca‐ses ,treated with corticosteroid and anti‐helicobacter pylori treatment) .The platelet parameters ,platelet associated immunoglobulin and some lymphocyte subsets were analyzed .Results Ninety seven children infected with Hp were found in 142 ITP children (69 . 7% ) .In the mean time ,37 children infected with Hp were observed in 92 healthy children (40 .2% ) .After treatment of 6 months , the PLT ,PCT ,CD3+ ,CD3+CD4+ and CD3+ CD4+ /CD3+ CD8+ of ITP children in both group were increased ,and the increased degree of those parameters were much higher in combined drug group than those in single drug group (P< 0 .01) .However ,the MPV ,PDW ,PAIgG ,PAIgA and CD3+ CD8+ were more decreased than that of the single drug group(P<0 .01) .Conclusion The ITP children have a higher infection rate of Hp ,which may be involved in the pathogenesis of ITP .Anti‐helicobacter pylori therapy would improve the therapy efficacy of ITP children infected with Hp by improving their immunity .
