The clinical change of cytokines expression in peripheral blood in patients with allergic asthma
10.3969/j.issn.1671-8348.2015.04.018
- VernacularTitle:过敏性哮喘患者外周血细胞因子水平变化及临床意义
- Author:
Weihong SHEN
;
Fang GONG
;
Lan ZHU
;
Jianping SHI
- Publication Type:Journal Article
- Keywords:
interleukin-17;
interleukin-22;
interleukin-10;
allergic asthma
- From:
Chongqing Medicine
2015;(4):485-486
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical change of cytokines expression in peripheral blood in patients with allergic asthma and its significance .Methods Forty patients with allergic asthma and thirty healthy controls were enrolled .The concentrations of IL‐17 ,IL‐22 and IL‐10 in peripheral blood were measured by ELISA ;the serum IgE levels were measured by electrochemical lumi‐nescence method ;The eosinophil proportion was detected by blood cell analyzer ;the IL‐17 ,IL‐22 ,IL‐10 and the severity of asthma were conducted Pearson correlation analysis .Results The level of serum IgE and eosinophil proportion was significantly higher in patients with allergic asthma compared with the controls (P<0 .05);compared with the control group ,the concentration of IL‐17 and IL‐22 in peripheral blood of patients with allergic asthma were increased ,but the expression of IL‐10 were decreased (P<0 .05);the level of IL‐17 and IL‐22 were positively correlated with severity of allergic asthma (P<0 .01) ,but the level of IL‐10 was negatively correlated with severity of allergic asthma (P<0 .05) .Conclusion The expression of IL‐17 ,IL‐22 and IL‐10 play an im‐portant role in the pathogenetic mechanism of allergic asthma ,and a dynamic monitoring could be helpful for the diagnoses and treatment of allergic asthma .
