Association of the TRAF1/C5 gene polymorphism with rheumatoid arthritis in Han population of Guizhou Province
10.3969/j.issn.1673-4130.2015.03.010
- VernacularTitle:贵州省汉族人群类风湿关节炎患者TRAF1/C5基因多态性研究
- Author:
Aifeng LIANG
;
Ying FEI
- Publication Type:Journal Article
- Keywords:
tumor necrosis factor receptor-associated factor;
complement component;
single nucleotide polymorphisms;
rheumatoid arthritis
- From:
International Journal of Laboratory Medicine
2015;(3):310-312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the tumor necrosis factor receptor-associated factor 1(TRAF1)/com-plement component 5(C5)single nucleotide polymorphism and rheumatoid arthritis patients.Methods Two groups of people were included in the study:300 rheumatoid arthritis(RA)patients(RA group)and 300 healthy individuals(control group).Real-time PCR was used to test the single nucleotide polymorphisms rs3761847 and rs10818488 of TRAF1/C5.Results There was no signifi-cant difference (P >0.05)of TRAF1/C5 rs3761847 and rs10818488 polymorphism between the two groups.The linkage disequilib-rium analysis results showed that there was strong linkage disequilibrium between rs3761847 and rs10818488.For the RF,anti-CCP and anti-Sa negative RA patients,the difference in the frequency of A allele of rs3761847 between the RA patients and matched con-trols was statistically significant(P =0.001,OR =0.57,95%CI :0.41 -0.79;P =0.001,OR =0.51,95%CI :0.35 -0.76;P =0.02,OR=0.72,95%CI :0.55-0.94).Significant difference for the frequency of G allele of rs10818488 between RF positive RA patients and control groups was observed(P =0.01,OR=1.40,95%CI :1.09-1.81).Conclusion TRAF1/C5 gene polymorphism may not associate with susceptibility of RA patients in Han population in Guizhou.
