Jiangtang decoction in combination with insulin in the treatmnet of type 1 diabetes mellitus in children
10.3760/cma.j.issn.1673-4246.2015.03.007
- VernacularTitle:自拟降糖饮联合注射胰岛素治疗儿童1型糖尿病的临床研究
- Author:
Qian LI
;
Yi CHAI
;
Yuping LENG
;
Yidong SHEN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 1 diabetes mellitus;
Insulin;
Drugs,Chinese herbal;
Child
- From:
International Journal of Traditional Chinese Medicine
2015;(3):217-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of the combination ofJiangtang decoction and insulin in the treatment of type 1 diabetes mellitus in children.Methods A total of 43 children with type 1 diabetes mellitus were enrolled and randomly allocated to either a insulin group (control group) and a insulin plusJiangtang decoction group (treatment group) using the table of random digits, with 23 patients in the control group and 20 in the treatment group. The patients in the control group were treated with insulin, and those in the treatment group were administrated withJiangtangdecoction on the basis of the treatment in the control group for 2 months. Body mass index (BMI), fasting plasma glucose (FPG), postprandial blood glucose (PBG) and hemoglobin A1c (HbA1c) were measured.Results The levels of FPG, PBG and HbA1c were significantly decreased in the treatment group (twere 3.376, 54.493, and 2.798, respectively; allP<0.01), and the PBG level was significantly decreased in the control group (t=29.714,P=0.000). The levels of FPG, PBG and HbA1c in the treatment group were significantly lower than those in the control group (twere 2.715, 2.191 and 5.627, respectively;P<0.05 orP<0.01). There was no difference in BMI between the treatment group and the control group (t=0.159,P=0.874). The proportion of patients with HbA1c <7.5% in the treatment group (60.0%, 12/20) was higher than that in the control group (26.1%, 6/23;χ2=5.055,P=0.025).Conclusion Combination ofJiangtang decoction and insulin can decrease the level of FPG, PBG and HbAlc, and its therapeutic effect is superior to insulin alone for type 1 diabetes in children.
