The effect ofShenmaiinjection on cardiac systolic and diastolic function of isolated myocardial infarction model rats
10.3760/cma.j.issn.1673-4246.2015.03.015
- VernacularTitle:参麦注射液对心肌梗死模型大鼠离体心脏舒缩功能的影响
- Author:
Yun LI
;
Kegang ZHU
;
Xianyu LI
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Heart rate;
Isometric tension;
Diastolic tension;
Shenmaiinjection;
Propranolol
- From:
International Journal of Traditional Chinese Medicine
2015;(3):247-250
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect ofShenmai injection on isolated cardiac systolic and diastolic function in myocardial infarction rats.Methods32 rats were randomly divided into a control group, a propranolol group, aShenmai + propranolol group and aShenmai group. The myocardial infarction models were made by ligating the left anterior descending coronary artery of rats .The heart was taken from myocardial infarction rat after 3 days. The indexes of Isometric tension (IT), Diastolic tension (DT), heart rate (HR), the maximum pressure ascending and descending rate of left ventricle (± LVdp/dtmax) (mmHg/s) were recorded by using Langendorff isolated heart perfusion technique at 5min before and 0.5 h, 1 h, 2 h after perfusion.ResultsCompared with the control group, the IT (2.01 ± 0.02 g, 1.52 ± 0.01 g, 1.53 ± 0.02 g), the HR (326 ± 32 time/min, 331 ± 41 time/min, 307 ± 37 time/min) and the ±LVdp/dtmax (4 012 ± 193 mmHg/s, 3 729 ± 174 mmHg/s, 3 631 ± 123 mmHg/s; 3 565 ± 202 mmHg/s, 3 632 ± 154 mmHg/s, 3 601 ± 129 mmHg/s) were apparently decreased in the propranolol group at 0.5 h, 1 h, 2 h after perfusion, and the differences were statistically significant (P<0.05). Compared with the control group, the IT (2.71 ± 0.10 g, 3.74 ± 0.04 g, 3.17 ± 0.01 g), the HR (491 ± 46 time/min, 527 ± 52 time/min, 519 ± 49 time/min) and the +LV dp/dtmax (5 690 ± 2 403 mmHg/s, 5 739 ± 219 mmHg/s, 5 825 ± 186 mmHg/s) were distinctly increased in theShenmaigroup at 0.5 h, 1 h, and 2 h after perfusion, and the differences were statistically significant (P<0.05). While the IT, DT, HR and ±LVdp/dtmax in theShenmai + propranolol group had no significant effect compared with the control group(P> 0.05).ConclusionsShenmaiinjection can improve myocardial contractility in isolated heart of myocardial infarction rats, however, propranolol can completely block the strong heart effect ofShenmaiinjection. This suggests thatShenmai injection has a beta receptor agonist effect.
