Literature analysis of adverse reaction induced by compoundDanshen injection

VernacularTitle:复方丹参注射液不良反应文献分析
Author: Jianteng NI ; Meng ZHONG ; Kuijun ZHAO
Publication Type:Journal Article
Keywords: CompoundDansheninjection; Adverse drug reactions; Chinese patent drugs
From: International Journal of Traditional Chinese Medicine 2015;(3):269-271
CountryChina
Language:Chinese
Abstract: Objective In order to investigate the situation application of compound Danshen injection (CDI) in the treatment and to provide reference for clinical rational use.Methods Adverse drug reactions (ADR) report literatures through WANFANG DATA, VIP DATA and CNKI from 1989 to 2013 with (CDI) were retrieved the data including patient age, gender, medical history, dosage, medication time and ADR type were got and analyzed.Results One hundred and twenty-one literatures with one hundred and forty-eight ADR report cases wore retrieved. The ADR of (CDI) rate of male was higher than female. The original disease causes were cardiovascular and cerebrovascular diseases. The age, a rather elderly bunch, was not associated with the disease. The frequent onest time of adverse reaction was in 5-20 min after medication, and allergic reaction was the main adverse reaction.Conclusion The ADR of CDI should not be ignored. Patients constitution, gender, medication time and the combined application should be pay more attention to reduce the incidence of ADR and ensure the drug safety.