Effects of infant antibiotic usage on childhood asthma morbidity
10.3969/j.issn.1000-3606.2015.02.001
- VernacularTitle:关注婴幼儿期抗生素使用对儿童哮喘发病的影响
- Author:
Jianhua ZHANG
;
Runfang HU
- Publication Type:Journal Article
- Keywords:
infant;
antibiotics;
children;
asthma
- From:
Journal of Clinical Pediatrics
2015;(2):101-104
- CountryChina
- Language:Chinese
-
Abstract:
According to clinical epidemiological researches, the usage of antibiotics in infant increases the risk of childhood asthma morbidity. The mechanism of this link is not entirely clariifed, and it is assumed of being related to side effects of antibiotics, which changes the colonization of normal intestinal lfora and reduces the diversity. It is clear that normal intestinal lfora of infant help to construct innate immune system and adaptive immune system, and forge immune tolerance. Therefore, normal intestinal lfora might be helpful in reducing allergies. The usage of antibiotics in early life changes the quantity and the composition of intestinal lfora, and breaks the balance of immune homeostasis, which might increase the risk of asthma morbidity. The abuse of antibiotics in children is a general phenomenon in China which needs attention from pediatricians.
