A study of bisphenol A and precocious puberty in 6-8 years old girls
10.3969/j.issn.1000-3606.2015.02.014
- VernacularTitle:双酚A与女童性早熟的关系
- Author:
Haiying WU
;
Linqi CHEN
;
Fengyun WANG
;
Xiuli CHEN
;
Rongrong XIE
;
Ting CHEN
;
Guangzhao HE
;
Weipeng WANG
- Publication Type:Journal Article
- Keywords:
bisphenol A;
precocious puberty;
kisspeptin;
girl
- From:
Journal of Clinical Pediatrics
2015;(2):155-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between bisphenol A and precocious puberty in 6-8 years girls. Meth-ods Atotal of 103 girls aged 6-8 years with precocious puberty in our Endocrine clinic from August to December 2012 were se-lected. According to the classiifcation standard of precocious puberty, girls are divided into idiopathic central precocious puberty (ICPP) group (n=47) and permature thelarche (PT) group (n=56), 53 girls with no puberty development were chosen as control group. BPA concentrations were determined with HPLC-MS-MS, sex hormones were determined with chemiluminescence meth-od and Kisspeptin concentrations were determined with ELISA, then the differences among the three groups were compared and the relationships between bisphenol A and sex hormones and Kisspeptin were analyzed. Results The BPA relevance ratio and concentration in ICPP group were higher than those of PT group and control group (P<0.05). The peak concentration of LH and LH/FSH in ICPP group were higher than those of PT group (P<0.05). The concentration of E2 in ICPP group and PT group were higher than that of control group (P<0.05). The concentration of Kisspeptin in ICPP group was higher than that of PT group and control group (P<0.05). There were no relationship between the concentrations of bisphenol A and Kisspeptin and FSH peak con-centration (P>0.05). There were correlations between the concentrations of BPA and E2 and LH peak concentration and LH/FSH (P<0.05). Conclusions There is a certain correlation between the concentrations of BPA and ICPP.
