Polymorphism analysis of thymidylate synthase in 252 colorectal cancer patients
10.3969/j.issn.1673-4130.2015.03.026
- VernacularTitle:252例结直肠癌患者胸苷酸合成酶基因多态性分析
- Author:
Xiaobo JIN
;
Nanqiu PENG
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
thymidylate synthase;
polymorphism
- From:
International Journal of Laboratory Medicine
2015;(3):347-349
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the polymorphism of thymidylate synthase(TS)in colorectal cancer patients,further more,to provide guidance for personalized therapy of colorectal cancer.Methods PCR direct sequencing was used to detect the polymor-phism of TS in 252 patients with colorectal cancer.Results TS genotypes of 252 patients with colorectal cancer were detected total-ly,including 137 male and 115 female.3RG/3RC accounted for the largest proportion in both male and female(36.50% and 36.52%respectively).In female,2RC/3RC and 3RG/3RG both accounted for the second largest proportion(both 18.25%).While in fe-male,3RG/3RC accounted for the second largest proportion(26.09%).If patients were divided according to age groups,in youth patients(n=28),3RG/3RC accounted for the largest proportion(42.86%),and the second was 2RC/3RG(21.43%).In the middle aged patients(n=84),3RG/3RC(45.24%)and 2RC/3RC(16.67%)were the major genotypes.For old patients(n=115),the ma-jor genotypes were 3RG/3RC(36.52%)and 2RC/3RG(16.52%).Conclusion The polymorphism of TS are mainly 3RG/3RC in colorectal cancer patients.
