The regulatory role of chemerin in infant with respiratory syncytial virus pneumonia
10.3969/j.issn.1000-3606.2015.02.004
- VernacularTitle:Chemerin在婴幼儿呼吸道合胞病毒肺炎中的调节作用
- Author:
Tingting JIN
;
Mingzhi ZHANG
;
Libo WANG
;
Aizhen LU
;
Xiaobo ZHANG
- Publication Type:Journal Article
- Keywords:
respiratory syncytial virus;
chemerin;
pneumonia;
cytokine;
infant
- From:
Journal of Clinical Pediatrics
2015;(2):113-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the regulatory role of chemerin in infant with respiratory syncytial virus (RSV) pneumonia by investigating the level of serum chemerin,pro-inlfammatory cytokine (TNF-α, IL-17), and anti-inlfammatory cytokine (IL-10, TGF-β). Methods The serum level of chemerin,TNF-α,IL-1,IL-10,TGF-βwere tested in 82 RSV pneumonia inpatients (17 severe RSV pneumonia cases,65 mild cases) and 40 controls by ELISA and the severity of the RSV pneumonia was evaluated using a scoring system. Results The serum level of chemerin of RSV pneumonia cases were (610.45±106.63pg/ml) which were signiifcantly higher than the control(337.24±43.37 pg/ml). Chemerin level of severe RSV pneumonia group is signiifcantly higher than mild cases as well [(786.62±82.59 pg/ml)vs (539.98±65.86 pg/ml)P<0.01 ]. Signiifcant positive correlations were found be-tween serum chemerin level and TNF-α,IL-17 level (r=0.81,r=0.61;P<0.01) while the serum level of chemerin is negatively correlated with IL-10, TGF-β(r=-0.80,r=-0.75;P<0.01). Conclusions The level of chemerin increased in RSV pneumonia patients,and related to clinical severity after RSV infection. These results indicate that chemerin may play an important role in the pathogenesis of RSV pneumonia and to the severity of the infection.
