Clinical features and influencing factors in neonatal coagulant function abnormality in the first 24 hours after birth
10.3969/j.issn.1000-3606.2015.02.010
- VernacularTitle:出生后24 h凝血功能异常新生儿临床表现及影响因素分析
- Author:
Hongwei HAN
;
Sheng DING
;
Hong CHEN
- Publication Type:Journal Article
- Keywords:
coagulant function abnormality;
inlfuenced factor;
newborn
- From:
Journal of Clinical Pediatrics
2015;(2):141-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical manifestations and inlfuencing factors in the newborns with coagulant function abnormality in the ifrst 24 hours after birth. Methods The coagulation test results and clinical data of 169 newborns in our hospital were studied. Children receiving anticoagulant therapy were assigned as coagulation abnormalities group (n=76) and other healthy newborns were assigned as control group (n=93). The differences of coagulation function between the two groups were analyzed and the inlfuencing factors of coagulation abnormalities were explored. Results The proportions of fetal distress, pneumonia, acidosis and hypothermia of coagulation abnormalities group were signiifcantly higher than that of the control group (χ2=6.18–38.01, P<0.05). Logistic regression analysis showed that fetal distress (OR=12.06, 95%CI:3.71–39.25), pneumonia (OR=4.10, 95%CI: 1.43–11.74) were the high risk factors for coagulant function abnormality, and the differences were statistically signiifcant (both P<0.05). Conclusions Fetal distress, pneumonia were the high risk factors for coagulant function abnormality. Early prevention can help to reduce the incidence of neonatal hemorrhagic disease.
