The clinical significance of HLA-B27 antigen detection in the diagnosis of ankylosing spondylitis
10.3969/j.issn.1673-4130.2015.03.036
- VernacularTitle:HLA-B27抗原检测在强直性脊柱炎诊断中的意义
- Author:
Wei LIN
;
Ping XIAO
;
Zuchang WU
- Publication Type:Journal Article
- Keywords:
ankylosing spondylitis;
human leukocyte antigen B27;
flow cytometry
- From:
International Journal of Laboratory Medicine
2015;(3):371-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the expression of human leukocyte antigen B27(HLA-B27)antigen and ankylosing spondylitis(AS),and its implications for the diagnosis and differential diagnosis of AS.Methods Flow cytometry was used to detect HLA-B27.354 suspected AS patients,35 patients final diagnosed with AS and 30 patients diagnosed with rheu-matoid arthritis(RA)were enrolled in the study.Results The positive rate of HLA-B27 in 354 patients with suspected AS was 22.0%,in patients diagnosed with AS was 85.7%,which was higher than the RA group(P <0.05).In AS patients,Males accoun-ted for 77.1%,females accounted for 22.9%,and the patients′age mainly concentrated in youth.The sensitivity and specificity of HLA-B27 test was 85.7% and 100.0% respectively in the diagnosis of AS.Conclusion HLA-B27 antigen detection is important for early diagnosis and differential diagnosis of AS patients.
