Expression and clinical significance of p63 in nodular lymphocyte predominance Hodgkin lymphoma and classical Hodgkin lymphoma

VernacularTitle:结节性淋巴细胞为主型霍奇金淋巴瘤与经典型霍奇金淋巴瘤中p63表达及临床意义
Author: Xin CHEN ; Xingan YE ; Zhizhong CHEN ; Chen WANG ; Liyu CAO
Publication Type:Journal Article
Keywords: nodular lymphocyte predominant Hodgkin lymphoma; classical Hodgkin lymphoma; p63; immunohistochemistry
From: Chinese Journal of Clinical and Experimental Pathology 2015;(1):52-54
CountryChina
Language:Chinese
Abstract: Purpose To investigate the expression and clinical significance of p63 in nodular lymphocyte predominant Hodgkin lym-phoma (NLPHL) and classical Hodgkin lymphoma (CHL). Methods 15 cases of NLPHL and 54 cases of CHL were stained for CD45, CD30, p63, PAX5, CD20, CD15, Oct-2, BOB1, MUM1, EMA, EBV-LMP1 and Ki-67 by immunohistochemical methods of EliVision. EBER were detected by in situ hybridization method in 12 cases of CHL. Results The expression of p63 in NLPHL (53. 3%, 8/15) was significantly higher than that in CHL (0, 0/54) (P<0. 05). Conclusions p63 protein is frequently expressed in NLPHL and helpful in the differential diagnosis between NLPHL and CHL.