Clinicopathologic analyses of Castleman′s disease and review of the literature
10.13315/j.cnki.cjcep.2015.01.015
- VernacularTitle:Castleman病临床病理分析并文献复习
- Author:
Hongyan HAN
;
Xiaobing LI
;
Bo ZHANG
;
Yun SHAO
;
Huaitao WANG
;
Chunwei XU
;
Fengxia ZHANG
- Publication Type:Journal Article
- Keywords:
Castleman′s disease;
clinical pathology;
etiology;
pathogenesis;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To describe clinicopathological features, diagnosis and differential diagnosis of Castleman′s disease. Methods Retrospective analyses of the clinical data, clinicopathology and immunohistochemistry were conducted in ten cases of Castleman dis-ease and reviewed of literature. Results There were 8 cases of unicenrtic Castleman′s disease and 2 cases of multicentric Castleman′s disease. Pathologically, there were 6 cases of hayline vascular types, one case of plasmatcyic type and 3 cases of mixed type in all Castleman′s disease. Immunohistochemically, all cases were negative for BCL-6 and CD10, and Ki-67 expression was less than or e-qual to 30%. There were 4 cases with complete follow-up data, including one case of intermediate type, 3 cases of hyaline vascular type which were healed by surgical resection without recurrence. Conclusions Castleman′s disease is a rare and lymphoproliferative disorders with unknown cause, it is not easy to diagnose before the operation. Whether immunohistochemical features reflect abnormal immune function or play unknown role in the pathogenesis of Castleman′s disease is also demanded further study.
