The association of MAFB gene polymorphism with nonsyndromic cleft lip with or without cleft palate in Ningxia Hui and Han population
10.3969/j.issn.1001-3733.2015.01.013
- VernacularTitle:MAFB 基因多态性在宁夏回汉人群中与非综合征型唇腭裂的相关性研究
- Author:
Lijuan MA
;
Xuefei DU
;
Wen DONG
;
Zhongwei ZHOU
;
Xiong YANG
;
Yanhua XIN
;
Jian MA
;
Min JIANG
;
Yongqing HUANG
- Publication Type:Journal Article
- Keywords:
Non-syndromic cleft lip with or without cleft palate(NSCL/P);
MAFB;
Single nucleotide polymor-phisms(SNPs)
- From:
Journal of Practical Stomatology
2015;(1):57-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the association between non-syndrome cleft lip and palate (NSCL/P)and MAFB (rs6072081, rs6065259,rs17820943,rs11696257)gene polymorphism in NingXia Hui and Han population.Methods:512 cases of NSCL/P,258 case of Hui nationality and 254 of Han,174 cases of complete 3 core family members(patients and their parents),142 cases of single parents families(patients and their single parents),were collected in patient group.505 cases of healthy newborns were collected in control group.The MAFB gene SNPs were determined with TaqMan SNPs genotyping methods and the data were analyzed by case-con-trol analysis,transmission disequilibrium test(TDT)and family based association test(FBAT).Results:Case-control analysis found that,there was a statistical significance of the genotypes and allele frequency between patients and the controls in MAFB of the 4 locus (P <0.05);but all of the 4 locus showed no difference in patients with cleft palate(P >0.05).Conclusion:The 4 locus single nucle-otide polymorphism was associated with NSCL/P in Ningxia population.
