Association between folate metabolism-related genes and non-syndromic cleft lip and palate in the popu-lation of Shanxi Province
10.3969/j.issn.1001-3733.2015.01.022
- VernacularTitle:叶酸代谢相关基因多态性与山西地区非综合征性唇腭裂的相关性研究
- Author:
Xinrong NAN
;
Yixiong REN
;
Ruifang LI
;
Jiangbo WANG
- Publication Type:Journal Article
- Keywords:
Methylenetetrahydrofolate reductase(MTHFR);
Methylenetetrahydrofolate dehydrogenase 1(MTH-FD1);
Polymorphism;
Non-syndromic cleft lip with cleft palate(NSCL/P)
- From:
Journal of Practical Stomatology
2015;(1):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of the rsl801133 polymorphisms of the methylenetetrahydrofolate reductase (MTHFR)gene and rs2236225 polymorphisms of the methylenetetrahydrofolate dehydrogenase(MTHFD1)gene with non-syndromic cleft lip with or without cleft palate (NSCL/P)in Chinese population of Shanxi Province.Methods:The rsl801133 polymorphism of MTHFR gene and rs2236225 polymorphism of MTHFD1 gene were examined by PCR-RFLP in 265 patients with NSCL/P and 276 healthy controls.Data were statistically analysed.Results:The genotypic distribution of rsl801133 and rs2236225 was not deviated from the Hardy-Weinberg equilibrium.There was no significant difference in allele frequencies of rsl801133 and rs2236225 variants between patients with NSCL/P and healthy individuals(P <0.05).Conclusion:The polymorphism of MTHFR gene and MTHFD1 gene was not associated with NSCL/P in Chinese population of Shanxi Province.
