Wnt5a involves the inflammation process and bone destruction in chronic periodontitis
10.3969/j.issn.1001-3733.2015.01.026
- VernacularTitle:Wnt5a 参与慢性牙周炎的炎症过程和骨破坏
- Author:
Huanzhi CHENG
;
Xiuqiu GAO
- Publication Type:Journal Article
- Keywords:
Chronic periodontitis;
Wnt5a;
Clinical attachment loss
- From:
Journal of Practical Stomatology
2015;(1):112-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of Wnt5a in gingival tissues of the patients with chronic periodontitis.Methods:Wnt5a expression was tested with RT-PCR and Western-Blot in gingival tissues in 20 cases of chronic periodontitis and 20 correspond-ing normal tissues.Results:In the gingival tissues of chronic periodontitis cases Wnt5a overexpression was found comparing with nor-mal tissues(P <0.05).The higher clinical attachment loss was correlated with the higher expression of Wnt5a.Conclusion:Wnt5a may affect the course of the inflammatory process and alveolar bone destruction in patients with chronic periodontitis.
