Expression of zeb-1 and c-jun in gastric carcinoma and its significance
10.13315/j.cnki.cjcep.2015.01.012
- VernacularTitle:胃癌组织中zeb-1和c-jun蛋白的表达及意义
- Author:
Zhiyong WANG
;
Jifeng WU
- Publication Type:Journal Article
- Keywords:
gastric neoplasm;
epithelial-mesenchymal transition;
zeb-1;
c-jun;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(1):48-51
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the expression of zeb-1 and c-jun in gastric cancer and its influence of occurrence and development of tumor. Methods The expression zeb-1, c-jun and E-cadherin were assessed in 100 specimens of gastric cancer and their tissue adja-cent to cancer by immunohistochemistry. Results The positive rates of zeb-1,c-jun and E-cadherin expression in gastric cancer were 81%, 70%, 35%, and in tissue adjacent to cancer were 17%, 25%, 100%. The expression of zeb-1 and c-jun in gastric cancer were higher than those in their tissue adjacent to cancer (P<0. 05). zeb-1 expression was closely correlated with the degree of tumor differentiation, depth of invasion, lymph node metastasis and TNM stage (P<0. 05), which were not correlated with patient s age, sex and tumor size. c-jun expression was closely correlated with the degree of tumor differentiation (P<0. 05), which were not correlated with other pathological features. The expression of zeb-1 was negatively correlated with the expression of E-cadherin and was positively correlated with the expression of c-jun in gastric cancer. Patients with high expression of zeb-1 and c-jun had lower five-year survival rate than patients with negative expression. Conclusion zeb-1 and c-jun are closely correlated with occurrence and development of gastric cancer. They can be a index of judging prognosis of gastric cancer.
