Gegenqinlian decoction decreases serum TNF-αlevel in rats with chronic periodontitis and atherosclerosis

VernacularTitle:葛根芩连汤对慢性牙周炎合并动脉粥样硬化大鼠血清 TNF-α水平的影响
Author: Wenjuan LI ; Wei PENG ; Dan WANG
Publication Type:Journal Article
Keywords: Gegenqinlian decoction; Atorvastatin Ting; Metronidazole; Periodontitis; Atherosclerosis; TNF-α
From: Journal of Practical Stomatology 2015;(1):23-26
CountryChina
Language:Chinese
Abstract: Objective:To investigate the effect of gegenqinlian on serum TNF-αlevel in rats with chronic periodontitis and athero-sclerotic.Methods:40 healthy male Wistar rats were randomly divided into control group(N,n =10)and model group(D,n =30).After model establishment and identfication the rats in model group were divided into D1,D2,D3,D4 and D5 groups(n =5) and were administered with saline,metronidazole,atorvastatin,metronidazole combined with atorvastatin and gegenqinlian respec-tively for 4 weeks.Periodontal indexes(PD and AL)were measured,the maximum intima-media thickness of abdominal aorta(IMT) was pathologically examined,TNF-αlevel was detected by ELISA.Results:After treatment PD,AL and serum TNF-αlevels in D2,D3,D4 and D5 groups were significantly lower than those in D1 group(P <0.05),There was no difference of lipid and TNF-αlevels between D4 and D5 groups(P >0.05).Conclusion:Gegenqinlian can reduce serum level of TNF-αin rats,suggesting that the drug is effective in the treatment of periodontitis with atherosclerosis.