Effects of Zhengan Xifeng Decoction on Blood Pressure and Gastrointestinal Motility in Spontaneously Hypertensive Rats
10.3969/j.issn.1005-5304.2015.03.018
- VernacularTitle:镇肝熄风汤对自发性高血压大鼠血压与胃肠动力的影响
- Author:
Chunlu YAN
;
Hua JIN
;
Fenglin LIU
;
Ronghai DOU
;
Xinyang WEN
;
Li CHEN
;
Qiuju ZHANG
;
Houqian XU
- Publication Type:Journal Article
- Keywords:
Zhengan Xifeng Decoction;
spontaneously hypertensive rats;
blood pressure;
gastrointestinal motility
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(3):69-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influencing mechanism of Zhengan Xifeng Decoction on blood pressure and gastrointestinal motility in SHR. Methods After 15 WKY and 90 SHR rats were were randomly divided into normal control group, model group, Benner Pury group, amlodipine group, Zhengan Xifeng Decoction high, middle, and low dose groups. The normal control group and model group were fed with distilled water daily. Rats in treatment group were administered with corresponding drugs daily. Blood pressure, gastric residual and intestinal propulsive ratio of rats was detected after eight-week intervention. Results Compared with the blank control group, systolic pressure, diastolic pressure, and mean arterial pressure were significantly higher than WKY rats of same age (P<0.05). Compared with the model group, the systolic pressure, diastolic pressure, and mean arterial pressure of treatment groups were significantly reduced (P<0.05). Compared with the blank control group, gastric residual rate of rats in the model group significantly decreased (P<0.05). Compared with the model group, the gastric residual rate in Zhengan Xifeng high dose group increased significantly, and intestinal propulsive ratio significantly increased (P<0.05), without statistical significance in the other treatment groups. Conclusion Zhengan Xifeng Decoction can reduce blood pressure in SHR, and regulate gastrointestinal motility.
