Effects of intensive insulin therapy on the level of inflammatory factors and prognosis in severe multiple trauma patients

VernacularTitle:强化胰岛素治疗对严重多发伤患者炎症因子水平及预后的影响
Author: Peng HE ; Qingshan ZHOU
Publication Type:Journal Article
Keywords: intensive insulin therapy; severe multiple trauma patients; inflammatory factors
From: Journal of Clinical Surgery 2015;(2):122-124
CountryChina
Language:Chinese
Abstract: Objective To observe the influence of intensive insulin therapy on inflammatory fac-tors and prognosis in severe multiple trauma patients.Methods A total of 53 cases of severe multiple trauma were randomly divided into the treatment group(n =27)and the control group(n =26).Besides basic treatment,patients in the treatment group received additional intensive insulin therapy by micro-pump.The level of blood glucose in the control group was controlled under 11.1 mmol/L.Levels of TNF-α,IL-1β,IL-6,and CRP were tested before and after treatment.Multiple organ dysfunction syndrome,noso-comial infection rate,and mortality rate were also observed.Results The levels of TNF-α,IL-1β,IL-6, and CRP in the treatment group were significantly lower than those of the control group(P <0.05 or P <0.01).The incidence of multiple organ dysfunction syndrome,nosocomial infection,and mortality rate in the treatment group was lower(P <0.05).Conclusion Intensive insulin therapy can effectively decrease the expressions of inflammatory factors in patients with severe multiple trauma,improve the prognosis,re-duce the incidence of nosocomial infection and mortality.