Axillary lymph node dissection for breast cancer patients with negative sentinel node biopsy:a sys-temic review
10.3969/j.issn.1005-6483.2015.02.017
- VernacularTitle:腋窝淋巴结清扫术治疗前哨淋巴结活检阴性乳腺癌的系统评价
- Author:
Qi WU
;
Juanjuan LI
;
Shengrong SUN
- Publication Type:Journal Article
- Keywords:
sentinel lymph node biopsy;
axillary lymph node dissection;
breast cancer;
systematic review
- From:
Journal of Clinical Surgery
2015;(2):128-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the effectiveness and safety of axillary lymph node dissection for breast cancer patients with negative sentinel node biopsy.Methods Literatures in CNKI,PubMed,EMBASE and CBMwere searched from their establishment to December 1,2013.Accord-ing to the inclusion and exclusion criteria,trials of axillary lymph node dissection and sentinel node biopsy for breast cancer were strictly screened and extracted for quality assessment and result analysis.Meta-anal-ysis was conducted by using Revman 5.1 software.Results A total of 10 studies involving 7731 patients were eligible for the final analysis.Because of the large differences in research type,measurement indica-tor,follow-up period and statistical index,subgroup analysis was adopted.Meta-analysis was applied for homogeneous researches and the remaining studies were analyzed with qualitative descriptive analysis.The results showed no significant differences in disease-free survival,overall survival,local recurrence rate,and distant metastasis rate in different follow-up periods.Conclusion For breast cancer patients with single invasive lesion,axillary lymph node dissection is not necessary.More high-quality random control trials and long-term follow-up are required to confirm the conclusions of this systematic review.
