Correlation between IL-23R gene polymorphisms and susceptibility of ankylo-sing spondylitis
10.3969/j.issn.1000-484X.2015.02.019
- VernacularTitle:IL-23 R基因多态性与吉林人群强直性脊柱炎易感性的关联研究
- Author:
Jilin ZHANG
;
Chong LIU
;
Xuemei SHAN
;
Yuguo SONG
- Publication Type:Journal Article
- Keywords:
Ankylosing spondylitis;
Interleukin-23 receptor ( IL-23R );
Single nucleotide polymorphism ( SNP );
Susceptibility;
Gene
- From:
Chinese Journal of Immunology
2015;(2):230-235
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between single nucleotide polymorphism ( SNP ) of rs7517847 and rs10489629 on IL-23R gene and susceptibility of ankylosing spondylitis in Jilin.Methods:IL-23R gene polymorphisms of 188 cases on ankylosing spondylitis were detected by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) , compared with those of 100 cases of healthy control group.Results:The frequency distribution differences ,between AS group and comparison group of separate genotype and the allele on two SNPs (rs7517847 and rs10489629) both showed statistical significance (P<0.05).Meanwhile, by the assumed genetic way , compared homozygous mutant GG of rs 7517847 with TG+TT, compared homozygous mutant AA of rs10489629 with GA+GG,such frequency distribution difference between the above two groups also showed statistical significance ( P<0.05).Conclusion:Polymorphisms about IL-23R gene of the rs7517847 and rs10489629 are both associated with susceptibility of AS in Jilin.The risk of AS will be increased if the person both with G/A allele and GG/AA genotype , which may be one of susceptive factors by AS.
