Study on levels of IFN-γ,IL-6,IL-17 and TGF-β1 in patients with Graves′disease
10.3969/j.issn.1000-484X.2015.02.022
- VernacularTitle:细胞因子IFN-γ、IL-6、IL-17和TGF-β1在Graves病发病中的作用
- Author:
Honglin LI
;
Meihua GAO
;
Yunhui ZHENG
;
Shijun YANG
;
Yanqiu LIU
;
Weiping LU
- Publication Type:Journal Article
- Keywords:
Graves′disease;
Cytokine;
Interleukin 17;
Transforming growth-beta;
Pathogensis
- From:
Chinese Journal of Immunology
2015;(2):253-256
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of cytokines in the pathogenesis of Graves′disease(GD),by detecting the levels of IFN-γ,IL-6,IL-17 and TGF-β1 in GD patients who were newly diagnosed.Methods:A total of 23 patients with new onset GD and 23 gender-and age-matched healthy controls were examined.The levels of serum IFN-γ, IL-6, IL-17 and TGF-β1 were measured by ELISA,FT3,FT4 and TSH levels were determined by ECL IA;TrAb levels were tested by RRA.Results: There were no significant difference among GD and NC group in sex and age match ( t=0.334 8 ,P>0.05;χ2=0.410 7 ,P>0.05 ).The levels of serum IFN-γ,IL-6,IL-17 and TGF-β1 in the GD group were significantly higher than the control group ( P<0.05 ) .Correlation analysis revealed that IFN-γ,IL-6,IL-17 and TGF-β1 were positively correlated with FT3,FT4(r=0.324 6,0.453 2,0.431 0,0.463 8;0.413 2,0.441 5, 0.436 2,0.467 1;P<0.05 ).Conclusion: IFN-γ, IL-6, IL-17 and TGF-β1 are highly expressed in the newly diagnosed GD patients.They play an important role in the pathogenesis of GD ,and provide helpful evaluation indices of immune dysfunction to Graves disease.
