Research progress of double-hit B cell lymphoma
10.3760/cma.j.issn.1009-9921.2014.10.015
- VernacularTitle:多重打击B细胞淋巴瘤的研究进展
- Author:
Yuan HUANG
- Publication Type:Journal Article
- Keywords:
Double-hit B cell lymphoma;
Pathogenesis;
Treatment
- From:
Journal of Leukemia & Lymphoma
2014;23(10):626-629
- CountryChina
- Language:Chinese
-
Abstract:
Double-hit B cell lymphoma refers to a group of mature B cell lymphoma presented with MYC/8q24 rearrangement with one or more concurrent chromosomal translocations.The first and most common translocation ever found is t(14;18)(q32;q21) involving BCL2.Other breakpoint types include MYC+/ BCL2+/BCL6+,MYC+/BCL6+,CCND1+/MYC+,BCL3+/MYC+ et al.This article reviewed the recent publications about the double-hit B cell lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma.The contents of the review include epidemiology,clinical characteristics,histopathology,treatment,prognosis and some prospects for future work.
