Effect of dihydroartemisinin on cell proliferation and radiotherapy sensitization of lung cancer cell H1299
10.3969/j.issn.1000-484X.2015.02.010
- VernacularTitle:双氢青蒿素对肺癌细胞株H1299增殖与放疗增敏的影响
- Author:
Kui LIAO
;
Zhiling WANG
;
Zhiping PENG
;
Haiyu LI
;
Juan LI
- Publication Type:Journal Article
- Keywords:
Dihydroartemisinin;
Non-small cell lung cancer;
Proliferation;
Cell cycle;
Radiation sensitivity
- From:
Chinese Journal of Immunology
2015;(2):185-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the inhibitory effect of dihydroartemisinin on non-small cell lung cancer H1299 cells.Methods:Through the CCK-8 method for determining the IC 10 of dihydroartemisinin ,choose low dose IC 10 as the experimental concentration,CCK-8 to observe artemisinin in low doses of H1299 cell proliferation, cycle and the influence of radiation sensitivity.Results:IC10 of dihydroartemisinin was 14.87 μmol/L,dihydroartemisinin could inhibit proliferation of H 1299 cells,slow down the cell cycle , and increased the radiation sensitivity.Conclusion: Dihydroartemisinin can inhibit cell proliferation , cell cycle arrest in S phase ,increase the radiation sensitivity.
