Vacuum sealing drainage with biological foam dressing accelerates the healing of chronic wounds:changes in gelatinase activity
10.3969/j.issn.2095-4344.2015.25.025
- VernacularTitle:生物泡沫敷料覆盖封闭负压引流加速慢性创面愈合中活性明胶酶的变化
- Author:
Ping YANG
;
Hongwei YAN
;
Hui GONG
;
Hua LIU
;
Zhimin NI
;
Shizheng TIAN
- Publication Type:Journal Article
- Keywords:
Drainage;
Negative-Pressure Wound Therapy;
Wound Healing;
Matrix Metal oproteinases;
Treatment Outcome
- From:
Chinese Journal of Tissue Engineering Research
2015;(25):4064-4068
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Studies have shown that vacuum sealing drainage can accelerate wound healing through increasing the wound blood flow, but its influence on activated gelatinases in human chronic wound stil lacks corresponding research. OBJECTIVE:To observe the effect of vacuum sealing drainage on the activity of gelatinase during the healing of chronic wounds. METHODS:Total y 96 trauma patients admitted at the People’s Hospital of Hubei University of Medicine from April 2013 to January 2014 were divided into two groups:52 patients in chronic wound group were treated with vacuum sealing drainage and 44 in control group treated with wound drainage at 3 days after removal of breast cancer. In the chronic wound group, exudates from pressure sores and skin necrosis after removal of breast cancer were col ected as samples A and B;exudates from two cases of venous stasis ulcer were col ected as samples C and D;exudates from traumatic skin wounds col ected as sample E. RESULTS AND CONCLUSION:TLC analyzer showed that:after 15-day negative pressure therapy, activities of matrix metal oproteinase 2 in sample A with low activity of gelatinase, matrix metal oproteinase 9 in sample B, matrix metal oproteinase 2 and 9 in samples C, D, E were al increased significantly (P<0.05);however, the activities of matrix metal oproteinase 9 in sample A with high activity of gelatinases and matrix metal oproteinase 2 in sample B were reduced significantly after treatment (P<0.05). In addition, no significant difference was found in the activity of matrix metal oproteinase 2, matrix metal oproteinase 9 and activated gelatinase betweenthe chronic wound group and control group (P>0.05). These findings indicate that the variation of activated gelatinases activity in human chronic wounds may be the reason why the chronic wounds cannot be healed for a long time, but vacuum sealing drainage can regulate the activity of activated gelatinases in chronic wounds.
