Relationship between the international prognosis indexes and the cell-mediated immunity condition in DLBCL patients
10.3760/cma.j.issn.1009-9921.2012.05.008
- VernacularTitle:弥漫大B细胞淋巴瘤细胞免疫状态与国际预后指数的关系
- Author:
Xin XU
;
Qingshan LI
;
Yanli XU
;
Zhigang ZHU
;
Weijie ZHONG
- Publication Type:Journal Article
- Keywords:
Lymphoma,large cell,diffuse;
Immunity,cellular;
T lymphocyte subsets;
Killer cells,natural;
International prognosis index
- From:
Journal of Leukemia & Lymphoma
2012;21(5):285-287
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relationship between the international prognosis indexes(IPT) and the cell-mediated immunity condition in DLBCL patients. Methods52 DLBCL patients were divided into 4 groups and the FCM was used to examine the T lymphocyte subsets,including CD3+、CD4+、CD8+、NK cells.T lymphocyte subsets absolute value and CD4+/CD8+ ratio were examined. Correlation with IPI were compared among groups.ResultsCD3+ cells in high risk group [(1570.9±370.5)/μl]were higher than other IPI groups;CD4+ cells in DLBCL groups were all lower than normal group(751.3±367.4)/μl]; CD8+ cells in high risk group [(1055.9±523.8)/μl] were higher than other groups; CD4+/CD8+ ratio in middle-high risk group and high risk group (1.0±0.2、0.7±1.0)were lower than other IPI groups and normal group;NK cells in middle-high risk group and high risk group were lower than the normal group[(199.5±68.4)/μl、(171.9±126.9)/μl];Age,clinical stage,body state had correlated with the CD3+ 、CD8+ cells and CD4+/CD8+ ratio of the DLBCL patients' peripheralblood T lymphosyte subsets. ConclusionsThe immunity condition in DLBCL patients has correlated with IPI; With increasing IPI value,the immunity depression and disorder become more serious,NK cells function become worse,and the prognosis is bad too.
