Internal medical management of extranodal nasal type NK/T cell lymphoma
10.3760/cma.j.issn.1673-422X.2015.01.019
- VernacularTitle:结外鼻型NK/T细胞淋巴瘤的内科治疗
- Author:
Jingjing WANG
;
Mei DONG
- Publication Type:Journal Article
- Keywords:
Lymphoma,extranodal NK-T-cell;
Drug therapy;
Hematopoietic stem cell transplantation
- From:
Journal of International Oncology
2015;42(1):71-73
- CountryChina
- Language:Chinese
-
Abstract:
Extranodal nasal type NK/T cell lymphoma (ENKTL) is a highly aggressive non-Hodgkin lymphoma.Due to its low occurrence even in prevalent areas,there has been no large sample randomized controlled clinical trials.Therefore,no standard therapeutic strategy is currently identified in this disease.Tumor cells are insensitive to conventional anthracyclines-containing chemotherapy because of high expression of multi-drug resistant gene 1.Regimens that incorporate the use of L-asparaginase or gemcitabine result in substantial improvements in overall response rate and are promising treatment for ENKTL.Targeted therapy,immunomodulatory therapy and hematopoietic stem cell transplantation are still under research.
