Clinicopathologic features of 112 patients with mantle cell lymphoma
10.3969/j.issn.1000-8179.20141779
- VernacularTitle:112例套细胞淋巴瘤临床病理分析
- Author:
Dongmei ZHOU
;
Gang CHEN
;
Xiongwei ZHENG
;
Weifeng ZHU
;
Baozhen CHEN
- Publication Type:Journal Article
- Keywords:
mantle cell lymphoma;
immunohistochemistry;
fluorescence in situ hybridization;
prognosis
- From:
Chinese Journal of Clinical Oncology
2015;(2):82-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL). Methods:Da-ta from 112 MCL cases were collected, and immunohistochemical assay was conducted. A break in the CCND1 gene was detected by fluorescence in situ hybridization (FISH). The t-test was used in the statistical analysis. Results:All tumor cells in the 112 cases ex-pressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all the cases, 106 expressed CD5 and 104 expressed cyclinD1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was found in 2 classical cases. Conclusion:MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.
