Bioinformatics study on human miRNA-Ebola virus interaction
10.7644/j.issn.1674-9960.2015.01.002
- VernacularTitle:人miRNA-埃博拉病毒相互作用的生物信息学研究
- Author:
Tao LIU
;
Jiang WANG
;
Zheng WANG
;
Xiaofei ZHENG
;
Wuju LI
- Publication Type:Journal Article
- Keywords:
miRNA;
Ebola virus;
interaction;
bioinformatics
- From:
Military Medical Sciences
2015;(1):6-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the interaction between human microRNA ( miRNA) and 5′trailer regions of Ebola virus genome from the perspective of bioinformatics so as to facilitate prevention and treatment of Ebola virus .Method The miRNA target prediction software Pita and RNAhybrid were used to predict the human miRNAs which could bind the 5′trailer regions of Ebola virus genomes before the miRNAs were annotated by g:Profiler web server .Results and Conclusion There may be complex interactions between human miRNAs and the 5′trailer regions of Ebola virus .Previous reports about the interaction between host miRNA and 5′trailer region of virus genome suggest that the interaction between human miRNA and 5′trailer region of Ebola virus may have effect on replication of Ebola virus and human cells .This work may provide new ideas on prevention and treatment of Ebola virus .
