Association between polymorphism ofGRIN3A gene and clinical characteristic in children with Kawasaki disease
10.3969/j.issn.1000-3606.2015.07.002
- VernacularTitle:GRIN3A基因多态性与川崎病的相关性分析
- Author:
Xiangqun JIN
;
Zhi XIONG
;
Ying ZHU
;
Lina TONG
;
Liqiong WANG
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
GRIN3A gene;
polymorphism;
clinical characteristic;
child
- From:
Journal of Clinical Pediatrics
2015;(7):605-608
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the association between nucleotide polymorphisms ofGRIN3A gene and clinical characteristic of Kawasaki disease (KD) in children in Han population in central Chinese.MethodsA case-control study was performed. A total of 191 children with KD were recruited and 217 healthy children were served as controls. The distribution of SNP was determined by PCR-RFLP. Arterial lesions were detected by echocardiographic.ResultsThe distribution of three genotypes (CC, CG, GG) in SNP (rs7849782) was statistically difference between KD and control groups (P=0.034), and C allele was associated with KD susceptibility (OR=1.46, 95%CI: 1.10-1.92,P=0.007). In children with KD, the polymorphism of SNP loci was signiifcantly associated with oral mucosa lesions and coronary artery lesion (P<0.05), but not associated with conjuncti-val hyperemia, hand-foot edema, rash, and lymphadenopathy (P>0.05). The polymorphism of SNP loci was also associated with the levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) (P<0.05).ConclusionThe ploymorphism of SNP loci ofGRIN3A gene (rs7849782) was associated with the susceptibility of KD. The C allele was the risk factors. The poly-morphism of SNP was associated with oral mucosa lesions and coronary artery lesion, and may affect the levels of ESR and CRP.
