The relationship between total IgE and atopic dermatitis in maternal serum and neonatal umbilical cord blood and allergen testing
10.11958/j.issn.0253-9896.2015.07.022
- VernacularTitle:产妇血清和新生儿脐带血中总IgE与特应性皮炎的关系及过敏原检测
- Author:
Sanwu ZENG
;
Linghe MENG
;
Deling WANG
;
Yingxue ZOU
;
Naijun TANG
;
Xu CHEN
;
Wenguo WEI
;
Jingji JIN
;
Fang QI
;
Danfeng SUO
- Publication Type:Journal Article
- Keywords:
dermatitis atopic;
fetal blood;
immunoglobulin E;
atopic dermatitis;
cord blood;
maternal serum;
total IgE;
specific IgE;
allergen test
- From:
Tianjin Medical Journal
2015;(7):781-783
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of total IgE and childhood atopic dermatitis (AD) in maternal serum and newborn cord blood, as well as its clinical significance of allergen testing. Methods Thirty-five cases diagnosed as AD (AD group) were selected, and other 35 children who were not diagnosed as AD (control group) were randomly selected from a birth cohort established in 2009—2011. The total IgE levels were detected by ELISA in maternal serum and newborn cord blood. The serum specific IgE antibody level was detected by quantitative immunoblotting method. Results The serum total IgE level was significantly higher in mother and newborn cord blood in AD group than that in control group (χ2=16.568 and 14.933, P<0.01). Compared to control group, there was a significantly higher positive rate of mother serum allergen includ?ing dust mites, house dust, ragweed pollen, song kind of pollen, poplar, surname and elm pollen, mould, shrimp, marine fish, in AD group (P<0.05). There was a significantly higher positive rate of artemisia pollen and fungi IgE in newborn cord blood in AD group (P<0.05). Conclusion The increased total IgE in maternal serum may play a predictive effect on infants suf?fering from AD. There is no obvious consistency in allergic state between mothers and infants.
