Research progress on the role of CaMKⅡin cardiovascular disease

VernacularTitle:CaMKⅡ在心血管疾病中作用的研究进展
Author: Pu WANG ; Yangong LIU ; Mingqi ZHENG
Publication Type:Journal Article
Keywords: calcium-calmodulin-dependent protein kinase type 2; sodium channels; ryanodine receptor calcium release channel; heart failure; arrhythmias,cardiac; review
From: Tianjin Medical Journal 2015;(7):813-817
CountryChina
Language:Chinese
Abstract: Calcium/calmodulin-dependent protein kinaseⅡ (CaMKⅡ) has multiple functions, which made it play a central role in cardiovascular disease. Especially it activates numerous downstream targets in various signaling pathways that promotes vascular disease, heart failure, myocardial hypertrophy and arrhythmias. CaMKⅡcan impact calcium balance and increase calcium leak in myocardial cell via phosphorylating L type calcium channel, Ryanodine receptor (RyR 2) and phos?pholamban (PLN), and regulate ATP sensitive potassium current (IKATP) and late sodium current by affecting sodium channels and potassium channels. In addition, It can directly regulate transcription via activating the silk crack the original activated protein kinases (MAPKs) and acetylation enzyme (HDAC). These mechanisms have important roles in myocardial hypertro?phy, heart failure and arrhythmia. So we focus to demonstrating the structure and action mechanism of CaMKⅡto improve a new therapy of cardiovascular disease.