Research progress of early brain injury mechanism after subarachnoid hemorrhage
10.16571/j.cnki.1008-8199.2015.07.021
- VernacularTitle:蛛网膜下腔出血后早期脑损伤机制研究进展
- Author:
Xiaoke HAO
;
Jixin SHI
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Early brain injury;
Apoptosis
- From:
Journal of Medical Postgraduates
2015;(7):767-770
- CountryChina
- Language:Chinese
-
Abstract:
Subarachnoid hemorrhage ( SAH) especially aneurismal SAH is a deadly cerebrovascular disorder with very high mortality and morbidity rates, but there is still no effective treatment in clinical practice.In recent years, more and more studies have suggested that early brain injury ( EBI) may be the main factor for poor prognosis of SAH.The pathogenesis of EBI after SAH includes a series of complicated pathophysiological changes.This paper reviews the related progress of EBI after SAH from the aspects of acute cerebral ischemia, the disruption of blood brain barrier, apoptosis, autophagy, oxidative stress, inflammation, and so on.
