Application of MR diffusion kurtosis imaging in grading of astrocytic tumors

VernacularTitle:磁共振扩散峰度成像在星形细胞肿瘤分级中的应用
Author: Mingrui YANG ; Xingyue JIANG ; Taiming NIE ; Jing WANG ; Di ZHANG ; Wen REN
Publication Type:Journal Article
Keywords: diffusion kurtosis imaging; astrocytic tumors; diagnostic classification
From: Journal of Practical Radiology 2015;(5):714-717
CountryChina
Language:Chinese
Abstract: Objective To investigate the value of magnetic resonance (MR)diffusion kurtosis imaging (DKI)in diagnostic classi-fication of astrocytic tumors.Methods 31 patients with astrocytic tumors confirmed by operation and pathology were collected,in-cluding low-grade tumors (WHO gradeⅠ and Ⅱ)in 14 and high-grade ones (WHO grade Ⅲ and Ⅳ)in 1 7.Routine MRI and DKI scan were preoperatively conducted using Siemens 3.0T MR scanner.Mean kurtosis (MK),radial kurtosis (RK)and axial kurtosis (AK)values were calculated in the solid portion of the tumors and the contralateral normal white matter.Results The MK,RK and AK values in tumors were lower than those in contralateral normal white matter,and were significantly higher in high-grade tumors than those in low-grade ones (P <0.05).Conclusion The MK,RK and AK values obtained by DKI reflect the histological structure changes of the astrocytic tumors.DKI is helpful for the diagnostic classification of astrocytic tumors,exhibiting more value in optimi-zing the treatment.