Clinical and genetic features of Barth syndrome in three patients
10.3969/j.issn.1000-3606.2015.07.004
- VernacularTitle:Barth综合征3例临床表现及基因突变分析
- Author:
Lin SHI
;
Lijun FU
;
Meirong HUANG
;
Ying GUO
;
Jian WANG
- Publication Type:Journal Article
- Keywords:
Barth syndrome;
cardiomyopathy;
TAZ gene
- From:
Journal of Clinical Pediatrics
2015;(7):614-617
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the clinical presentation, diagnosis, treatment, and outcome of the Barth syndrome (BTHS).MethodsClinical data were collected and analyzed from 3 patients with conifrmed genetic diagnosis of BTHS from June 2013 to October 2014.ResultsAll of the 3 patients were males and two of them were twins. The main clinical manifes-tations of the 3 patients were cardiomyopathy and heart failure, accompanied by different degrees of trabeculations of the left ventricle. Two of them were diagnosed of left ventricular noncompaction (LVNC). All of the 3 patients presented with motor retardation, muscle weakness, growth delay and signiifcantly increased urinary excretion of 3-methylglutaconic acid (3-MGC). One patient was found to have neutropenia. All 3 patients hadTAZ gene mutations which included a novel missense mutation (c.527A>G, p.H176R) detected in the twins and a known nonsense mutation (c.367C>T, p.R123X) identiifed in the other patient. All of the mutations were inherited from their mothers. During the follow-up, the twins died at 7 months old and 7.5 months old respectively. The other patient was still alive.ConclusionBTHS is one of the causes of cardiomyopathy in children. In the male patients who presented with muscle weakness, neutropenia, and increased urinary excretion of 3-MGC, especially in those com-bined with LVNC, BTHS should be screened.
