Value of citrulline, intestinal fatty acid binding protein, and intestinal trefoil factor in the diagnosis of acute gastroin-testinal injury in critically ill children
10.3969/j.issn.1000-3606.2015.07.012
- VernacularTitle:瓜氨酸、肠型脂肪酸结合蛋白、肠三叶因子在儿童危重症急性胃肠损伤诊断中的作用
- Author:
Ni ZHANG
;
Wei ZHU
;
Jiarui ZHU
;
Weijun ZHANG
;
Aihua WANG
- Publication Type:Journal Article
- Keywords:
citrulline;
intestinal fatty acid binding protein;
intestinal trefoil factor;
acute gastrointestinal injury;
critically ill
- From:
Journal of Clinical Pediatrics
2015;(7):650-654
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the values of serum citrulline, intestinal fatty acid binding protein (IFABP) and intes-tinal trefoil factor (ITF) in diagnosis of acute gastrointestinal injury in critically ill children.MethodsA total of 84 critically ill children were enrolled. The serum citrullin, IFABP, and ITF were measured by high performance liquid chromatography and enzyme-linked immunosorbent assay. The testing results and clinical data were analyzed.ResultsCompared with non gastroin-testinal injury group, the serum citrulline level was signiifcantly lower and IFABP and ITF levels were signiifcantly higher in gas-trointestinal injury group (allP<0.05). In critically ill children, the serum citrulline level was negatively correlated with C-reactive protein, procalcitonin and hospitalization time (r=-0.36 to -0.31,P<0.01).ConclusionsThe levels of citrulline, IFABP and ITF have diagnostic values for acute gastrointestinal injury in critically ill children. The level of citrulline may relfect the degree of acute gastrointestinal injury in critically ill children.
