The study on dynamic changes of plasma D-dimer in elderly patients with acute exacerbation of COPD combined with type 2 diabetes mellitus
10.11958/j.issn.0253-9896.2015.07.023
- VernacularTitle:老年COPD急性加重期合并2型糖尿病患者血浆D-二聚体的动态变化
- Author:
Yanchun WANG
;
Junfeng ZHANG
;
Dianjun WEI
;
Chunli LIU
- Publication Type:Journal Article
- Keywords:
pulmonary disease,chronic obstructive;
diabetes mellitus,type 2;
C-reactive protein;
aged;
D-dimer
- From:
Tianjin Medical Journal
2015;(7):784-787
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate dynamic changes of plasma D-dimer, C-reactive protein (CRP) and fasting plas?ma glucose (FBG) levels in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with type 2 diabetes mellitus. Methods AECOPD group (n=65) was used as A group, AECOPD combined with type 2 diabetes mellitus group (n=65) was used as B group. Levels of D-dimer, CRP and FBG were observed and compared between two groups in the first day, the 3rd day, the 7th day and the 14th day after hospital admission. The correlation be?tween D-dimer, CRP and FBG was analyzed. Logistic regression analysis was used to estimate the factors affecting increased plasma levels of D-dimer. Results Levels of D-dimer, CRP and FBG were significantly higher in B group than those of A group in the first day, the 3rd day, the 7th after hospital admission (P<0.01). Values of D-dimer and CRP were declined ob?viously in A group in the 7th day after hospital admission, but in B group they were declined obviously until the 14th day. There was no significant difference in FBG of A group. The level of FBG was significantly decreased in B group. There was a positive correlation between D-dimer, CRP and FBG (P<0.05). Logistic regression analysis showed that CRP, FBG, p(O2) and age were the influence factors for the increased levels of D-dimer. Conclusion In elderly patients with AECOPD com?bined with type 2 diabetes mellitus, we should pay attention to anti-inflammatory and controlling blood sugar, and the dy?namic monitoring levels of D-dimer, which helps to improve the prognosis for patients with AECOPD, and reduce mortality.
