Research progress of miR-224 and tumor
10.11958/j.issn.0253-9896.2015.07.034
- VernacularTitle:miR-224与肿瘤关系的研究进展
- Author:
Maosheng LIU
;
Jixiang ZHANG
- Publication Type:Journal Article
- Keywords:
microRNAs;
neoplasms;
genes,tumor suppressor;
oncogenes;
review;
miR-224
- From:
Tianjin Medical Journal
2015;(7):826-829
- CountryChina
- Language:Chinese
-
Abstract:
miR-224 is a small noncoding RNA that usually binds to response element of target mRNA through the seed sequences,leading to the suppression of translation or mRNA degradation. Recent researches indicate that miR-224 not on?ly aberrantly expresses in multiple tumors(hepatocellular carcinoma,gastric carcinoma, diffuse large B-cell lymphoma, prostatecancer,colorectal cancer, etc),playing an important role in tumor suppressor or oncognen,but also has an effect on the chemosensitivity of tumor.In this article,we review recent studies about the mechanism of miR-224 in the tumor develop?ment ,progression and chemosensitivity.
