An update on pathogenesis and treatment of Glanzmann thrombasthenia
10.3969j.issn.1000-3606.2015.05.022
- VernacularTitle:遗传性血小板无力症发病机制及治疗进展
- Author:
Min GAO
- Publication Type:Journal Article
- Keywords:
platelet;
glanzmann thrombasthenia;
pathogenesis;
gene mutation;
treatment
- From:
Journal of Clinical Pediatrics
2015;33(5):486-489
- CountryChina
- Language:Chinese
-
Abstract:
Glanzmann thrombasthenia (GT) is an inherited disease of platelet function disorders characterized by mucocutaneous bleeding due to platelets failed to aggregate in response to physiologic stimuli. GT is a rare inherited disease and caused by quantitative or qualitative deifciencies of an integrin receptor GPⅡb/Ⅲa for adhesive proteins. There is no uniifed treatment strategy available so far for GT. This review summarizes the update of pathogenesis treatment progresses in GT.
