Impact of basic diseases on the clinical symptoms and prognosis of cryptococcosis
10.16571/j.cnki.1008-8199.2015.07.010
- VernacularTitle:基础疾病对隐球菌病患者临床症状和转归的影响
- Author:
Yuan DING
;
Mingming TAN
;
Di XIA
;
Qian HE
;
Yi SHI
;
Xin SU
- Publication Type:Journal Article
- Keywords:
Cryptococcosis;
Clinical feature;
Basic disease;
Prognosis
- From:
Journal of Medical Postgraduates
2015;(7):719-722
- CountryChina
- Language:Chinese
-
Abstract:
Objective Cryptococcosis is a potential life-threatening systemic mycosis with a heterogeneous susceptible popu-lation which is classified into three groups according to the current guidelines, including AIDS patients, organ transplantation recipients ( OTR) , and non-HIV-infected and non-transplant hosts ( NHNT) .This study aimed to discuss the influence of basic diseases on the clinical features and prognosis of NHNT cryptococcosis patients. Methods Using a retrospective cohort study design, we retrieved the clinical data about 73 NHNT cryptococcosis patients treated in Jinling Hospital.Based on the presence or absence of immunodefi-ciency or infection-increasing complications, we divided the patients into a basic disease group ( n=35) and a non-basic disease group ( n=38) and analyzed their clinical characteristics, chest radiographic features, laboratory results, and clinical outcomes. Results Compared with the non-basic disease group, the basic disease group showed a significantly higher incidence rate of disseminated disea-ses (62.9%vs 21.1%, P<0.01), more cases of patchy consolidation (47.4%vs 16.7%, P<0.05) and mixed lesion (31.6%vs 3.3%, P<0.05) in chest radiography, and a higher mortality (30.0%vs 5.3%, P=0.016). Conclusion Basic diseases have a great impact on the clinical features and prognosis of NHNT cryptococcosis.NHNT patients with basic diseases are susceptible to dis-seminated diseases with severer clinical symptoms and a higher mortality.
